Depends
A big enough bend radius shouldn't weaken the lanyard significantly, and think of it this way: a 3-hole deadeye gives you six legs of lanyard line, a four-hole eight--so the lanyard can be pretty skinny and still be plenty strong.
Will you be using Dyneema lanyards? You can use thinner line than if using polyester or hemp line, and the bend radius will be better for the same thickness of deadeye.
Ben
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